Endocrine Abstracts

Introduction: We report a rare case of hyperandrogenism associated with portal hypertension as a result of Alagille syndrome.Case report: 21-yr old female presented with primary amenorrhoea and mild hirsutism. There was no history of delayed puberty or acne. Past medical history: Alagille syndrome (biliary tree hypoplasia, liver disease, portal hypertension, splenomegaly, Barrett’s oesophagus and pulmonary stenosis). Drug ...

Background: Pituitary radiotherapy (RT) is known to have metabolic, cardiovascular and cerebrovascular complications due to the effects of radiation on normal pituitary tissue and surrounding neurological structures.Objectives: Retrospective evaluation of effects of RT on pituitary dysfunction, type 2 diabetes mellitus, cardio- and cerebrovascular morbidity and mortality in unselected consecutive pituitary adenomas ...

Introduction: We report a rare case of hyperandrogenism associated with portal hypertension as a result of Alagille syndrome.Case report: 21-yr old female presented with primary amenorrhoea and mild hirsutism. There was no history of delayed puberty or acne. Past medical history: Alagille syndrome (biliary tree hypoplasia, liver disease, portal hypertension, splenomegaly, Barrett’s oesophagus and pulmonary stenosis). Drug ...

Background: Pituitary radiotherapy (RT) is known to have metabolic, cardiovascular and cerebrovascular complications due to the effects of radiation on normal pituitary tissue and surrounding neurological structures.Objectives: Retrospective evaluation of effects of RT on pituitary dysfunction, type 2 diabetes mellitus, cardio- and cerebrovascular morbidity and mortality in unselected consecutive pituitary adenomas ...

Background: Adrenal crisis is a life threatening emergency with an incidence of 5–10 adrenal crises/100 patient-years with mortality around 0.5/100 patient-years.Objective: Audit of inpatient adrenal crisis management was undertaken in line with Society for Endocrinology (SFE) guidance 2016 (Trust audit No:9763).Methods: Retrospective evaluation of electronic and paper case records of 2 years (January 2017–December 2018)....

Background: Premature Ovarian Insufficiency (POI) is characterised by oligo-/amenorrhoea with elevated gonadotropins and low oestradiol before the age of 40 years.Objective: To evaluate management of non-Turner POI patients in line with European Society of Human Reproduction and Embryology (ESHRE) guidance (1)Methods: Retrospective evaluation of electronic and paper case records.Results: Over 23-year period (...